Highly permeable artificial water channels that can self-assemble into two-dimensional arrays.

نویسندگان

  • Yue-Xiao Shen
  • Wen Si
  • Mustafa Erbakan
  • Karl Decker
  • Rita De Zorzi
  • Patrick O Saboe
  • You Jung Kang
  • Sheereen Majd
  • Peter J Butler
  • Thomas Walz
  • Aleksei Aksimentiev
  • Jun-li Hou
  • Manish Kumar
چکیده

Bioinspired artificial water channels aim to combine the high permeability and selectivity of biological aquaporin (AQP) water channels with chemical stability. Here, we carefully characterized a class of artificial water channels, peptide-appended pillar[5]arenes (PAPs). The average single-channel osmotic water permeability for PAPs is 1.0(± 0.3) × 10(-14) cm(3)/s or 3.5(± 1.0) × 10(8) water molecules per s, which is in the range of AQPs (3.4 ∼ 40.3 × 10(8) water molecules per s) and their current synthetic analogs, carbon nanotubes (CNTs, 9.0 × 10(8) water molecules per s). This permeability is an order of magnitude higher than first-generation artificial water channels (20 to ∼ 10(7) water molecules per s). Furthermore, within lipid bilayers, PAP channels can self-assemble into 2D arrays. Relevant to permeable membrane design, the pore density of PAP channel arrays (∼ 2.6 × 10(5) pores per μm(2)) is two orders of magnitude higher than that of CNT membranes (0.1 ∼ 2.5 × 10(3) pores per μm(2)). PAP channels thus combine the advantages of biological channels and CNTs and improve upon them through their relatively simple synthesis, chemical stability, and propensity to form arrays.

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عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 112 32  شماره 

صفحات  -

تاریخ انتشار 2015